TOKYO – Vietnamese scientist Tran Dang Xuan and his colleagues at Hiroshima University, Japan have discovered anti-cancer agents in rice husks.
The research titled Cytotoxic Mechanism of Momilactones A and B against Acute Promyelocytic Leukemia and Multiple Myeloma Cell Lines was published in Cancers magazine in October this year, according to Vietnam news agency (VNA).
This is the first study clarifying the cytotoxic mechanism of Momilactones A (MA) and Momilactones B (MB) on acute promyelocytic leukaemia (APL) HL-60 and multiple myeloma (MM) U266 cell lines.
Besides, these compounds may induce G2 phase arrest in the HL-60 cell cycle through the activation of p-38 and disruption of CDK1 and cyclin B1 complex, it added.
This finding provides novel insights into the anticancer property of Momilactones, which can be a premise for future studies and the development of Momilactone-based anti-cancer medicines.
According to VNA, the Laboratory of Plant Physiology and Biochemistry at Hiroshima University led by Xuan is one of the few laboratories in the world that can purify Momilactones from natural sources such as rice. In a study in 2019, the group discovered and successfully extracted 600 mg of MA and MB from 30kg of rice husks.
The scientist said many pharmaceutical companies inside and outside Japan are working with his team to extract MA and MB for developing medicines to boost the immune system, anti-cancer medicines, those for treating diabetes, and cosmetics. – Bernama, November 3, 2022
